Figuring fact from fiction: unbiased polling of memory T cells

Carmen Gerlach; Scott M Loughhead; Ulrich H von Andrian

doi:10.1016/j.cell.2015.04.038

Figuring fact from fiction: unbiased polling of memory T cells

Cell. 2015 May 7;161(4):702-4. doi: 10.1016/j.cell.2015.04.038.

Authors

Carmen Gerlach¹, Scott M Loughhead¹, Ulrich H von Andrian²

Affiliations

¹ Harvard Medical School, Department of Microbiology and Immunobiology, Division of Immunology, Boston, MA 02115, USA.
² Harvard Medical School, Department of Microbiology and Immunobiology, Division of Immunology, Boston, MA 02115, USA; The Ragon Institute of MGH, MIT, and Harvard, 400 Technology Square, Cambridge, MA 02139, USA. Electronic address: uva@hms.harvard.edu.

PMID: 25957676
DOI: 10.1016/j.cell.2015.04.038

Abstract

Immunization generates several memory T cell subsets that differ in their migratory properties, anatomic distribution, and, hence, accessibility to investigation. In this issue, Steinert et al. demonstrate that what was believed to be a minor memory cell subset in peripheral tissues has been dramatically underestimated. Thus, current models of protective immunity require revision.

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MeSH terms

Animals
Arenaviridae Infections / immunology*
Immunologic Memory*
Lymphocytic choriomeningitis virus / physiology*
Monitoring, Immunologic*
T-Lymphocyte Subsets / immunology*