Leiomyosarcoma of Larynx as a Metachronous Tumor of Squamous Cell Carcinoma: An Unusual Case

J Voice. 2016 Mar;30(2):242-5. doi: 10.1016/j.jvoice.2015.04.011. Epub 2015 May 9.

Abstract

Leiomyosarcomas (LMSs) are malignant tumors of smooth muscles accounting for 5-6% of all soft tissue sarcomas. They are mostly seen in the gastrointestinal tractus, the uterus, and the retroperitoneum. Soft tissue sarcomas comprise <1% of all laryngeal malignancies, most of which are chondrosarcomas. Laryngeal LMSs are rarely seen malignancies, which are published as case reports. We presented a case of laryngeal LMS, which was seen 4 years later in a laryngeal squamous cell carcinoma patient who underwent laryngeal laser microsurgery. We discussed the diagnosis and treatment algorithm in the light of the present literature.

Keywords: Larynx; Leiomyosarcoma; Metachronous; Squamous cell carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis
  • Biopsy
  • Carcinoma, Squamous Cell / chemistry
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / surgery
  • Chemotherapy, Adjuvant
  • Head and Neck Neoplasms / chemistry
  • Head and Neck Neoplasms / pathology*
  • Head and Neck Neoplasms / surgery
  • Humans
  • Immunohistochemistry
  • Laryngeal Neoplasms / chemistry
  • Laryngeal Neoplasms / pathology*
  • Laryngeal Neoplasms / surgery
  • Laryngectomy / methods
  • Leiomyosarcoma / chemistry
  • Leiomyosarcoma / pathology*
  • Leiomyosarcoma / surgery
  • Magnetic Resonance Imaging
  • Male
  • Microsurgery
  • Neoplasms, Second Primary*
  • Predictive Value of Tests
  • Radiotherapy, Adjuvant
  • Squamous Cell Carcinoma of Head and Neck
  • Treatment Outcome

Substances

  • Biomarkers, Tumor