Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype

Marla M Jalbut; Aliyah R Sohani; Paola Dal Cin; Robert P Hasserjian; Jenna A Moran; Andrew M Brunner; Amir T Fathi

doi:10.1016/j.lrr.2015.04.001

Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype

Leuk Res Rep. 2015 Apr 22;4(1):28-30. doi: 10.1016/j.lrr.2015.04.001. eCollection 2015.

Authors

Marla M Jalbut¹, Aliyah R Sohani², Paola Dal Cin³, Robert P Hasserjian², Jenna A Moran², Andrew M Brunner², Amir T Fathi²

Affiliations

¹ Tufts University School of Medicine, Boston, MA, United States.
² Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
³ Brigham and Women׳s Hospital, Harvard Medical School, Boston, MA, United States.

Abstract

Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cytogenetic and subsequent FISH analyses revealed a constitutional 47,XXY karyotype. We also review and discuss relevant prior literature.

Keywords: Acute myeloid leukemia; Constitutional chromosomal abnormality; Klinefelter syndrome.

Publication types

Case Reports