Infiltrative lymphomatous optic neuropathy in non-Hodgkin lymphoma

Dickson Wong; Helen Danesh-Meyer; Jo-Anne Pon

doi:10.1016/j.jocn.2015.04.001

Infiltrative lymphomatous optic neuropathy in non-Hodgkin lymphoma

J Clin Neurosci. 2015 Sep;22(9):1513-5. doi: 10.1016/j.jocn.2015.04.001. Epub 2015 May 16.

Authors

Dickson Wong¹, Helen Danesh-Meyer², Jo-Anne Pon³

Affiliations

¹ Eye Department, Christchurch Public Hospital, 19 St Asaph Street, Christchurch 8011, New Zealand. Electronic address: dick23son@hotmail.com.
² University of Auckland, Auckland, New Zealand.
³ Eye Department, Christchurch Public Hospital, 19 St Asaph Street, Christchurch 8011, New Zealand.

PMID: 25986181
DOI: 10.1016/j.jocn.2015.04.001

Abstract

We report a 67-year-old man with non-Hodgkin lymphoma who presented with fluctuating visual loss which responded partially to steroid treatment. Multiple lumbar punctures did not show lymphoblastic cells and multiple MRI did not show any central nervous system disease except for isolated optic nerve enhancement. A fundus examination revealed combined arterial and venous occlusion and optic disc swelling. Due to conflicts between the examinations and investigations, there was a reluctance to initiate radiotherapy until progressive changes involving both eyes occurred. The man died 8 months after he was diagnosed with lymphoma. A post mortem optic nerve biopsy showed lymphomatous infiltration, confirming that the initial suspicion based on the clinical findings was correct.

Keywords: Lymphomatous infiltration; Non-Hodgkin lymphoma; Optic neuropathy.

Publication types

Case Reports

MeSH terms

Aged
Humans
Lymphoma, Non-Hodgkin / complications*
Lymphoma, Non-Hodgkin / pathology*
Magnetic Resonance Imaging
Male
Optic Nerve Diseases / etiology*