Surfactant enhancement of polyethyleneglycol-induced cell fusion

FEBS Lett. 1989 Dec 18;259(1):149-52. doi: 10.1016/0014-5793(89)81515-7.

Abstract

B16 mouse melanoma cells in monolayers may be satisfactorily fused with 50% PEG 1500. However, pre-treatment with detergents in solution at low concentrations significantly increases PEG fusion, up to 8-fold in some instances, without impairing cell viability. The practical and mechanistical implications of this finding are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Fusion / drug effects*
  • Cell Survival / drug effects
  • Detergents / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Mice
  • Polyethylene Glycols / pharmacology*
  • Surface-Active Agents / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Detergents
  • Surface-Active Agents
  • Polyethylene Glycols