IL-2: Change Structure … Change Function

Jeffrey A Bluestone; Natasha Crellin; Eleonora Trotta

doi:10.1016/j.immuni.2015.05.002

IL-2: Change Structure … Change Function

Immunity. 2015 May 19;42(5):779-81. doi: 10.1016/j.immuni.2015.05.002.

Authors

Jeffrey A Bluestone¹, Natasha Crellin², Eleonora Trotta³

Affiliations

¹ Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address: jeff.bluestone@ucsf.edu.
² Pfizer Centers for Therapeutic Innovation, San Francisco, CA 94158, USA.
³ Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.

PMID: 25992850
DOI: 10.1016/j.immuni.2015.05.002

Abstract

In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Antibodies / immunology*
Humans
Interleukin-2 / metabolism*
Models, Molecular*
T-Lymphocyte Subsets / cytology*
T-Lymphocyte Subsets / immunology*

Substances

Antibodies
Interleukin-2

Grants and funding

R01 AI046643/AI/NIAID NIH HHS/United States