Medical and Surgical Management of Carney Complex

J Card Surg. 2015 Jul;30(7):560-7. doi: 10.1111/jocs.12575. Epub 2015 May 21.

Abstract

Carney complex is a rare, autosomal dominant genetic disorder that consists of multiple myxomatous lesions and endocrine abnormalities, including skin lesions, cardiac myxomas, primary pigmented nodular adrenocortical disease, and acromegaly. This review discusses the medical and surgical treatment of patients with Carney complex.

Publication types

  • Review

MeSH terms

  • Adult
  • Age Factors
  • Cardiac Surgical Procedures
  • Carney Complex / diagnosis
  • Carney Complex / genetics
  • Carney Complex / mortality
  • Carney Complex / surgery*
  • Cause of Death
  • Chromosomes, Human, Pair 17 / genetics
  • Chromosomes, Human, Pair 2 / genetics
  • Cyclic AMP-Dependent Protein Kinase RIalpha Subunit / genetics
  • Echocardiography
  • Female
  • Genetic Counseling
  • Genetic Testing
  • Heart Neoplasms / diagnostic imaging
  • Heart Neoplasms / surgery
  • Humans
  • Male
  • Mutation
  • Myxoma / diagnostic imaging
  • Myxoma / surgery
  • Risk
  • Young Adult

Substances

  • Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
  • PRKAR1A protein, human