Abstract
The carotenoid compound trans-sodium crocetinate (TSC) has been shown to increase oxygenation in various tissues, including the brain. Notably, TSC can enhance oxygenation under conditions of reduced blood flow, thus attenuating the depth of an ischemic challenge. This study examined the impact of TSC on neuronal loss in an animal model of intracerebral hemorrhage (ICH). Utilizing a rat model of collagenase injection, TSC was shown to reduce perihematomal cellular loss after ICH, as assessed by Fluoro-Jade B staining in tissue sections. This is the first evidence demonstrating that TSC is capable of limiting hemorrhagic injury to neurons in the brain. The finding supports the concept that TSC may represent a candidate therapeutic for early intervention regardless of whether a stroke is hemorrhagic or ischemic in nature.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Carotenoids
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Caudate Nucleus / drug effects
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Caudate Nucleus / pathology
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Cell Count
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Cerebral Hemorrhage / chemically induced
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Cerebral Hemorrhage / complications
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Cerebral Hemorrhage / drug therapy*
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Cerebral Hemorrhage / pathology
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Collagenases / toxicity
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Drug Evaluation, Preclinical
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Fluoresceins / analysis
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Fluorescent Dyes / analysis
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Hematoma / complications
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Hematoma / drug therapy*
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Hematoma / pathology
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Male
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Nerve Degeneration / etiology
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Nerve Degeneration / pathology
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Nerve Degeneration / prevention & control
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Neurons / drug effects
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Neurons / pathology
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Neuroprotective Agents / therapeutic use*
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Putamen / drug effects
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Putamen / pathology
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Rabbits
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Rats
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Rats, Sprague-Dawley
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Vitamin A / analogs & derivatives*
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Vitamin A / therapeutic use
Substances
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Fluoresceins
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Fluorescent Dyes
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Neuroprotective Agents
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fluoro jade
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trans-sodium crocetinate
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Vitamin A
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Carotenoids
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Collagenases