Long noncoding RNAs: Re-writing dogmas of RNA processing and stability

Biochim Biophys Acta. 2016 Jan;1859(1):128-38. doi: 10.1016/j.bbagrm.2015.06.003. Epub 2015 Jun 11.

Abstract

Most of the human genome is transcribed, yielding a complex network of transcripts that includes tens of thousands of long noncoding RNAs. Many of these transcripts have a 5' cap and a poly(A) tail, yet some of the most abundant long noncoding RNAs are processed in unexpected ways and lack these canonical structures. Here, I highlight the mechanisms by which several of these well-characterized noncoding RNAs are generated, stabilized, and function. The MALAT1 and MEN β (NEAT1_2) long noncoding RNAs each accumulate to high levels in the nucleus, where they play critical roles in cancer progression and the formation of nuclear paraspeckles, respectively. Nevertheless, MALAT1 and MEN β are not polyadenylated as the tRNA biogenesis machinery generates their mature 3' ends. In place of a poly(A) tail, these transcripts are stabilized by highly conserved triple helical structures. Sno-lncRNAs likewise lack poly(A) tails and instead have snoRNA structures at their 5' and 3' ends. Recent work has additionally identified a number of abundant circular RNAs generated by the pre-mRNA splicing machinery that are resistant to degradation by exonucleases. As these various transcripts use non-canonical strategies to ensure their stability, it is becoming increasingly clear that long noncoding RNAs may often be regulated by unique post-transcriptional control mechanisms. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.

Keywords: CircRNA; Circular RNA; MALAT1; MEN β; NEAT1; Polyadenylation; Pre-mRNA splicing; RNA stability; Sno-lncRNA; Triple helix; tRNA-like.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Nucleus / genetics
  • Gene Expression Regulation
  • Humans
  • Poly A / genetics
  • RNA Precursors / genetics
  • RNA Processing, Post-Transcriptional / genetics*
  • RNA Splicing / genetics*
  • RNA Stability / genetics*
  • RNA, Long Noncoding / genetics*
  • RNA, Small Nucleolar / genetics

Substances

  • RNA Precursors
  • RNA, Long Noncoding
  • RNA, Small Nucleolar
  • Poly A