Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3256-60. doi: 10.1016/j.bmcl.2015.05.081. Epub 2015 May 31.

Abstract

Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.

Keywords: Anti-influenza; Cytopathic effect; Neuraminidase inhibition; Phellinus baumii; Polyphenol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales / chemistry*
  • Animals
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Basidiomycota / chemistry*
  • Cytopathogenic Effect, Viral / drug effects
  • Dogs
  • Dose-Response Relationship, Drug
  • Fruiting Bodies, Fungal / chemistry
  • Influenza A Virus, H1N1 Subtype / drug effects
  • Influenza A Virus, H1N1 Subtype / enzymology
  • Influenza A Virus, H3N2 Subtype / drug effects
  • Influenza A Virus, H3N2 Subtype / enzymology
  • Influenza A Virus, H5N1 Subtype / drug effects
  • Influenza A Virus, H5N1 Subtype / enzymology
  • Kinetics
  • Madin Darby Canine Kidney Cells
  • Medicine, East Asian Traditional
  • Neuraminidase / antagonists & inhibitors
  • Orthomyxoviridae / drug effects*
  • Orthomyxoviridae / enzymology
  • Polyphenols / chemistry
  • Polyphenols / isolation & purification
  • Polyphenols / pharmacology*

Substances

  • Antiviral Agents
  • Polyphenols
  • Neuraminidase