Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis

Mult Scler. 2016 Feb;22(2):245-9. doi: 10.1177/1352458515590647. Epub 2015 Jun 17.

Abstract

Background: The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown.

Objective: To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis.

Methods: CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls.

Results: CSF amounts of 78 kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p<0.01) and non-inflammatory controls (p<0.001) and in magnetic resonance imaging (MRI) inactive than in MRI active RRMS (p<0.00001).

Conclusion: Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS.

Keywords: CSF levels; HLA-G; MRI activity; Multiple Sclerosis; dimeric form.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blotting, Western
  • Brain / pathology*
  • Case-Control Studies
  • Dimerization
  • Female
  • HLA-G Antigens / cerebrospinal fluid*
  • Humans
  • Inflammation / cerebrospinal fluid
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / cerebrospinal fluid*
  • Multiple Sclerosis, Relapsing-Remitting / pathology
  • Nervous System Diseases / cerebrospinal fluid
  • Spinal Cord / pathology*

Substances

  • HLA-G Antigens