The detection of multiple DNA targets with a single probe using a conformation-sensitive acoustic sensor

Chem Commun (Camb). 2015 Jul 21;51(57):11504-7. doi: 10.1039/c5cc03436a.

Abstract

By using an acoustic wave methodology that allows direct sensing of biomolecular conformations, we achieved the detection of multiple target DNAs using a single probe, exploiting the fact that each bound target results in a hybridized product of a different shape.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustics / instrumentation*
  • Biosensing Techniques / instrumentation*
  • DNA / analysis*
  • DNA Probes / chemistry
  • MicroRNAs / analysis*
  • Nucleic Acid Conformation
  • Nucleic Acid Hybridization*
  • Quartz Crystal Microbalance Techniques / instrumentation
  • Sound*

Substances

  • DNA Probes
  • MicroRNAs
  • DNA