Mechanotransduction: use the force(s)

Ewa K Paluch; Celeste M Nelson; Nicolas Biais; Ben Fabry; Jens Moeller; Beth L Pruitt; Carina Wollnik; Galina Kudryasheva; Florian Rehfeldt; Walter Federle

doi:10.1186/s12915-015-0150-4

Mechanotransduction: use the force(s)

BMC Biol. 2015 Jul 4:13:47. doi: 10.1186/s12915-015-0150-4.

Authors

Affiliations

¹ MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK. e.paluch@ucl.ac.uk.
² Chemical & Biological Engineering, Princeton University, 303 Hoyt Laboratory, William Street, Princeton, NJ, 08544, USA.
³ Biology Department, Brooklyn College and the Graduate Center of the City University of New York, 2900 Bedford avenue, Brooklyn, NY, 11210, USA.
⁴ Department of Physics, University of Erlangen-Nuremberg, Henkestrasse 91, 91052, Erlangen, Germany.
⁵ Department of Mechanical Engineering, Microsystems Laboratory, Stanford University, 496 Lomita Mall, Durand Building Rm 102, Stanford, CA, 94305, USA.
⁶ Department of Mechanical Engineering and Molecular and Cellular Physiology, Microsystems Laboratory, Stanford University, by courtesy, 496 Lomita Mall, Durand Building Rm 213, Stanford, CA, 94305, USA.
⁷ Georg-August-University, 3rd Institute of Physics - Biophysics, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany.
⁸ Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK.

Abstract

Mechanotransduction - how cells sense physical forces and translate them into biochemical and biological responses - is a vibrant and rapidly-progressing field, and is important for a broad range of biological phenomena. This forum explores the role of mechanotransduction in a variety of cellular activities and highlights intriguing questions that deserve further attention.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Actomyosin / metabolism
Animals
Biomechanical Phenomena
Cell Adhesion
Focal Adhesions / metabolism
Humans
Kinetics
Locomotion
Mechanotransduction, Cellular*
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / metabolism
Stress Fibers / metabolism

Substances

Actomyosin

Abstract

Publication types

MeSH terms

Substances

Grants and funding