Interactome analysis brings splicing into focus

Daniel Dominguez; Christopher B Burge

doi:10.1186/s13059-015-0707-0

Interactome analysis brings splicing into focus

Genome Biol. 2015 Jul 7;16(1):135. doi: 10.1186/s13059-015-0707-0.

Authors

Daniel Dominguez¹, Christopher B Burge^{2

3}

Affiliations

¹ Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.
² Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. cburge@mit.edu.
³ Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. cburge@mit.edu.

Abstract

The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing.Please see related Research article: http://www.genomebiology.com/2015/16/1/119/abstract.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Alternative Splicing*
Heterogeneous Nuclear Ribonucleoprotein A1
Heterogeneous-Nuclear Ribonucleoprotein Group A-B / metabolism*
Humans
Serine-Arginine Splicing Factors / metabolism*
Spliceosomes / metabolism*

Substances

Heterogeneous Nuclear Ribonucleoprotein A1
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
SRSF1 protein, human
Serine-Arginine Splicing Factors