Phosphoinositide signaling in cancer: INPP4B Akt(s) out

John F Woolley; Irakli Dzneladze; Leonardo Salmena

doi:10.1016/j.molmed.2015.06.006

Phosphoinositide signaling in cancer: INPP4B Akt(s) out

Trends Mol Med. 2015 Sep;21(9):530-2. doi: 10.1016/j.molmed.2015.06.006. Epub 2015 Jul 3.

Authors

John F Woolley¹, Irakli Dzneladze², Leonardo Salmena³

Affiliations

¹ Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
² Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
³ Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address: leonardo.salmena@utoronto.ca.

PMID: 26150301
DOI: 10.1016/j.molmed.2015.06.006

Abstract

INPP4B acts as a tumor suppressor in various epithelial cancers by inhibiting PI3K/Akt signaling. Unexpectedly, tumor-promoting features of INPP4B in leukemia and breast cancer have been recently uncovered. In this spotlight, we discuss the seemingly paradoxical nature of INPP4B-mediated signaling in cancer.

Keywords: Akt; INPP4B; PI3K; oncogene; phosphoinositide; tumor suppressor.

MeSH terms

Humans
Neoplasms / enzymology*
Neoplasms / genetics
Neoplasms / metabolism
Phosphatidylinositols / metabolism*
Phosphoric Monoester Hydrolases / genetics
Phosphoric Monoester Hydrolases / metabolism*
Proto-Oncogene Proteins c-akt / genetics
Proto-Oncogene Proteins c-akt / metabolism*
Signal Transduction

Substances

Phosphatidylinositols
Proto-Oncogene Proteins c-akt
Phosphoric Monoester Hydrolases
phosphatidylinositol-3,4-bisphosphate 4-phosphatase