Efficient Palladium-Catalyzed C-H Fluorination of C(sp3)-H Bonds: Synthesis of β-Fluorinated Carboxylic Acids

Org Lett. 2015 Aug 7;17(15):3798-801. doi: 10.1021/acs.orglett.5b01774. Epub 2015 Jul 14.

Abstract

A novel and facile process for direct fluorination of unactivated C(sp3)-H bonds at the β position of carboxylic acids was accomplished by a palladium(II)-catalyzed C-H activation. The addition of Ag2O and pivalic acid was found to be crucial for the success of this transformation. This reaction provides a versatile strategy for the synthesis of β-fluorinated carboxylic acids.