Virological analysis of inherited chromosomally integrated human herpesvirus-6 in three hematopoietic stem cell transplant patients

Transpl Infect Dis. 2015 Oct;17(5):728-31. doi: 10.1111/tid.12419. Epub 2015 Aug 22.

Abstract

We analyzed 3 hematopoietic stem cell transplant (HSCT) recipients with inherited chromosomally integrated human herpesvirus-6 (inherited CIHHV-6). Cases 1 (inherited CIHHV-6A) and 2 (inherited CIHHV-6B) were inherited CIHHV-6 recipients. Case 3 received bone marrow from a donor with inherited CIHHV-6B. Following HSCT, HHV-6B was isolated from Case 1. HHV-6A and -6B messenger RNAs were detected in Cases 1 and 3.

Keywords: HSCT; RT-PCR; inherited CIHHV-6; reactivation.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Child, Preschool
  • DNA, Viral / isolation & purification*
  • Female
  • Hematopoietic Stem Cell Transplantation*
  • Herpesvirus 6, Human / genetics*
  • Herpesvirus 6, Human / isolation & purification
  • Humans
  • Male
  • Virus Integration*
  • Young Adult

Substances

  • DNA, Viral