Local Integration Accounts for Weak Selectivity of Mouse Neocortical Parvalbumin Interneurons

Benjamin Scholl; Jagruti J Pattadkal; Geoffrey A Dilly; Nicholas J Priebe; Boris V Zemelman

doi:10.1016/j.neuron.2015.06.030

Local Integration Accounts for Weak Selectivity of Mouse Neocortical Parvalbumin Interneurons

Neuron. 2015 Jul 15;87(2):424-36. doi: 10.1016/j.neuron.2015.06.030.

Authors

Benjamin Scholl¹, Jagruti J Pattadkal², Geoffrey A Dilly³, Nicholas J Priebe⁴, Boris V Zemelman⁵

Affiliations

¹ Center for Perceptual Systems, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department for Functional Architecture and Development of Cerebral Cortex, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458 USA.
² Center for Perceptual Systems, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA.
³ Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Center for Learning and Memory, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA.
⁴ Center for Perceptual Systems, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Center for Learning and Memory, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA. Electronic address: nico@austin.utexas.edu.
⁵ Department of Neuroscience, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Center for Learning and Memory, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA; Institute of Cell and Molecular Biology, The University of Texas at Austin, 2415 Speedway, Austin, TX 78712, USA.

Abstract

Dissecting the functional roles of excitatory and inhibitory neurons in cortical circuits is a fundamental goal in neuroscience. Of particular interest are their roles in emergent cortical computations such as binocular integration in primary visual cortex (V1). We measured the binocular response selectivity of genetically defined subpopulations of excitatory and inhibitory neurons. Parvalbumin (PV+) interneurons received strong inputs from both eyes but lacked selectivity for binocular disparity. Because broad selectivity could result from heterogeneous synaptic input from neighboring neurons, we examined how individual PV+ interneuron selectivity compared to that of the local neuronal network, which is primarily composed of excitatory neurons. PV+ neurons showed functional similarity to neighboring neuronal populations over spatial distances resembling measurements of synaptic connectivity. On the other hand, excitatory neurons expressing CaMKIIα displayed no such functional similarity with the neighboring population. Our findings suggest that broad selectivity of PV+ interneurons results from nonspecific integration within local networks. VIDEO ABSTRACT.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Action Potentials / physiology
Animals
Interneurons / physiology*
Luminescent Proteins / genetics
Luminescent Proteins / metabolism
Mice
Mice, Inbred C57BL
Mice, Transgenic
Models, Neurological
Neocortex / cytology*
Nerve Net / physiology*
Optogenetics
Parvalbumins / genetics
Parvalbumins / metabolism*
Patch-Clamp Techniques
Photic Stimulation
Principal Component Analysis

Substances

Luminescent Proteins
Parvalbumins

Abstract

Publication types

MeSH terms

Substances

Grants and funding