Design-based stereology is the gold standard of morphometry in lung research. Here, we analyze the current use of morphometric and stereological methods in lung research and provide an overview on recent methodological developments and biological observations made by the use of stereology. Based on this analysis we hope to provide useful recommendations for a good stereological practice to further the use of advanced and unbiased stereological methods.
Keywords: design-based stereology; emphysema; fibrosis; morphometry; serial block face scanning electron microscopy.
Copyright © 2015 the American Physiological Society.