Fatal toxic epidermal necrolysis in a patient on teriflunomide treatment for relapsing multiple sclerosis

Mult Scler. 2015 Oct;21(11):1476-7. doi: 10.1177/1352458515596601. Epub 2015 Jul 21.

Abstract

We report a case of toxic epidermal necrolysis in a 46-year-old woman on teriflunomide treatment. Such a severe adverse cutaneous drug reaction with this new therapy for relapsing forms of multiple sclerosis should be early recognized in order to ensure the rapid withdrawal of the drug.

Keywords: Teriflunomide; adverse effect; multiple sclerosis; toxic epidermal necrolysis.

Publication types

  • Case Reports

MeSH terms

  • Crotonates / adverse effects*
  • Fatal Outcome
  • Female
  • Humans
  • Hydroxybutyrates
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Nitriles
  • Stevens-Johnson Syndrome / etiology*
  • Toluidines / adverse effects*

Substances

  • Crotonates
  • Hydroxybutyrates
  • Nitriles
  • Toluidines
  • teriflunomide