Silica shelled and block copolymer encapsulated red-emissive AIE nanoparticles with 50% quantum yield for two-photon excited vascular imaging

Chem Commun (Camb). 2015 Sep 7;51(69):13416-9. doi: 10.1039/c5cc03603h.

Abstract

A polymer and silica co-protection strategy has been developed to encapsulate organic fluorogens with aggregation-induced emission and charge transfer characteristics into small nanoparticles (NPs). The co-pretected NPs show bright red fluorescence (50% quantum yield) with a large two-photon action cross-section (450 GM at 840 nm), which have been sucessfully used for two-photon fluorescence imaging of vasculature of the mouse tibial muscle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Vessels / pathology*
  • Lactones / chemistry
  • Mice
  • Muscle, Skeletal / pathology
  • Nanoparticles / chemistry*
  • Optical Imaging
  • Photons
  • Polyethylene Glycols / chemistry
  • Polymers / chemistry*
  • Silicon Dioxide / chemistry*

Substances

  • Lactones
  • Polymers
  • poly(ethylene glycol)-block-poly(epsilon-caprolactone)
  • Polyethylene Glycols
  • Silicon Dioxide