Abstract
Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology
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Doxorubicin / chemistry*
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Doxorubicin / metabolism
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Drug Delivery Systems / methods*
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Humans
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Hydrogen-Ion Concentration
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Hydrophobic and Hydrophilic Interactions
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Matrix Metalloproteinase 9 / chemistry*
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Matrix Metalloproteinase 9 / metabolism*
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Micelles
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Nanoparticles / chemistry*
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Polyethylene Glycols / chemistry
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Polymers / chemistry*
Substances
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Antineoplastic Agents
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Micelles
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Polymers
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Polyethylene Glycols
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Doxorubicin
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Matrix Metalloproteinase 9