Abstract
Reconstituted high-density lipoprotein (rHDL), a natural nanoparticle consisting of apolipoprotein A-I and phospholipids, was modified with a hydrophobic fluorescent dye before (pre-rHDL) and after (post-rHDL) reconstitution. Pre-rHDL particles had a similar size to unmodified rHDL, but post-rHDL particles were significantly larger and their avidity for a HDL receptor was 2.6 times of that shown by pre-rHDL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apolipoprotein A-I / chemistry*
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Apolipoprotein A-I / metabolism
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Cholesterol, VLDL / chemistry*
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Cholesterol, VLDL / metabolism
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Electrophoresis, Polyacrylamide Gel / methods*
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Lipoproteins, HDL / chemistry*
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Lipoproteins, HDL / metabolism
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Micelles
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Nanoparticles / chemistry*
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Phospholipids / chemistry
Substances
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Apolipoprotein A-I
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Cholesterol, VLDL
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Lipoproteins, HDL
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Micelles
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Phospholipids