Hyperferritinemic syndrome: Still's disease and catastrophic antiphospholipid syndrome triggered by fulminant Chikungunya infection: a case report of two patients

Clin Rheumatol. 2015 Nov;34(11):1989-92. doi: 10.1007/s10067-015-3040-9. Epub 2015 Aug 2.

Abstract

There are four medical conditions characterized by high levels of ferritin, the macrophage activation syndrome (MAS), adult onset Still' s disease (AOSD), catastrophic antiphospholipid syndrome (CAPS), and septic shock, that share similar clinical and laboratory features, suggesting a common pathogenic mechanism. This common syndrome entity is termed "the hyperferritinemic syndrome." Here, we describe two different cases of hyperferritinemic syndrome triggered by Chikungunya fever virus infection: a 21-year-old female with SLE and a 32-year-old male patient who developed AOSD after the coinfection of dengue and Chikungunya viruses.

Keywords: Adult onset Still’s disease; Catastrophic antiphospholipid syndrome; Chikungunya virus infection; Ferritin; Hyperferritinemic syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiphospholipid Syndrome / diagnosis
  • Antiphospholipid Syndrome / etiology*
  • Cataract / congenital*
  • Cataract / diagnosis
  • Cataract / etiology
  • Chikungunya Fever / complications*
  • Dengue / complications*
  • Female
  • Ferritins / blood
  • Fever
  • Humans
  • Iron Metabolism Disorders / congenital*
  • Iron Metabolism Disorders / diagnosis
  • Iron Metabolism Disorders / etiology
  • Lupus Erythematosus, Systemic
  • Male
  • Still's Disease, Adult-Onset / diagnosis
  • Still's Disease, Adult-Onset / etiology*
  • Young Adult

Substances

  • Ferritins

Supplementary concepts

  • Hyperferritinemia, hereditary, with congenital cataracts