Type 1 Diabetes and MicroRNA: It's Complicated

Curtis R Warren; Chad A Cowan

doi:10.1016/j.cmet.2015.07.018

Type 1 Diabetes and MicroRNA: It's Complicated

Cell Metab. 2015 Aug 4;22(2):202-3. doi: 10.1016/j.cmet.2015.07.018.

Authors

Curtis R Warren¹, Chad A Cowan²

Affiliations

¹ Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
² Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: chad_cowan@harvard.edu.

PMID: 26244930
DOI: 10.1016/j.cmet.2015.07.018

Abstract

Type 1 diabetes is an autoimmune disease that manifests as impaired insulin secretion, with compounding complications over time. Bhatt et al. (2015) investigate protective mechanisms in survivors of type 1 diabetes by using induced pluripotent stem cells as genetic models, uncovering novel interactions between microRNA and the DNA damage checkpoint pathway.

Publication types

Comment

MeSH terms

Cell Cycle Checkpoints*
DNA Damage*
Diabetes Mellitus, Type 1 / metabolism*
Female
Gene Expression Regulation*
Humans
Male
MicroRNAs / biosynthesis*
Models, Biological*

Substances

MicroRNAs