Nanoparticle-Loaded Protein-Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery

Adv Mater. 2015 Oct 7;27(37):5484-92. doi: 10.1002/adma.201502022. Epub 2015 Aug 11.

Abstract

A new formulation of volatile nanodroplets stabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug.

Keywords: breast cancer; chemotherapy; microbubbles; nanodroplets; ultrasound.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / pharmacokinetics
  • Cell Survival / drug effects
  • Drug Carriers* / chemistry
  • Drug Delivery Systems / methods
  • Drug Liberation
  • Equipment Design
  • Ferric Compounds* / chemistry
  • Fluorocarbons / chemistry
  • Humans
  • MCF-7 Cells
  • Magnetite Nanoparticles* / chemistry
  • Oleic Acid / chemistry
  • Paclitaxel / administration & dosage
  • Paclitaxel / pharmacokinetics
  • Polyethylene Glycols* / chemistry
  • Quaternary Ammonium Compounds* / chemistry
  • Serum Albumin* / chemistry
  • Ultrasonography / methods*

Substances

  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Drug Carriers
  • Ferric Compounds
  • Fluorocarbons
  • Magnetite Nanoparticles
  • Quaternary Ammonium Compounds
  • Serum Albumin
  • ferric oxide
  • Oleic Acid
  • Polyethylene Glycols
  • dodecyltrimethylammonium
  • Paclitaxel