Dectin-1 Exerts Dual Control in the Gut

Cell Host Microbe. 2015 Aug 12;18(2):139-41. doi: 10.1016/j.chom.2015.07.010.

Abstract

Dectin-1, a β-glucan receptor, contributes to host anti-fungal defense. In this issue of Cell Host & Microbe, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colitis by decreasing anti-microbial peptide production, which allows overgrowth of Lactobacilli and triggers T regulatory cell expansion in the gut.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Colitis / pathology*
  • Colon / immunology*
  • Colon / pathology*
  • Lactobacillus / immunology*
  • Lectins, C-Type / antagonists & inhibitors*
  • Signal Transduction*
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Lectins, C-Type