Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinson's disease symptoms without side effects

Chandramohan Wakade; Raymond Chong; Eric Bradley; John C Morgan

doi:10.1002/ccr3.232

Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinson's disease symptoms without side effects

Clin Case Rep. 2015 Jul;3(7):635-7. doi: 10.1002/ccr3.232. Epub 2015 Jun 11.

Authors

Chandramohan Wakade¹, Raymond Chong¹, Eric Bradley¹, John C Morgan²

Affiliations

¹ Department of Physical Therapy, Georgia Regents University 1120, 15th Street, Augusta, Georgia, 30912, USA.
² Department of Neurology, Georgia Regents University 1120, 15th Street, Augusta, Georgia, 30912, USA.

Abstract

A 65-year-old male, Parkinson's disease patient, was evaluated for GPR109A expression, niacin index, UPDRS scale, handwriting test, and quality of sleep with and without niacin treatment. The evaluation was repeated 3 months after niacin was stopped. Niacin modulated the abovementioned parameters and showed the overall improvement without side effects.

Keywords: GPR109A; Parkinson’s disease; inflammation; niacin.

Publication types

Case Reports