Memory NK Cells Take Out the (Mitochondrial) Garbage

Julia A Wagner; Todd A Fehniger

doi:10.1016/j.immuni.2015.08.009

Memory NK Cells Take Out the (Mitochondrial) Garbage

Immunity. 2015 Aug 18;43(2):218-20. doi: 10.1016/j.immuni.2015.08.009.

Authors

Julia A Wagner¹, Todd A Fehniger²

Affiliations

¹ Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
² Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: tfehnige@wustl.edu.

PMID: 26287678
DOI: 10.1016/j.immuni.2015.08.009

Abstract

The molecular mechanisms important to generate innate natural killer cell "memory" are poorly understood. In this issue of Immunity, O'Sullivan et al. (2015) demonstrate that mitophagy plays a critical role in natural killer cell memory formation following viral infection.

Publication types

Comment

MeSH terms

Animals
Herpesviridae Infections / immunology*
Killer Cells, Natural / immunology*
Membrane Proteins / metabolism*
Mitochondria / metabolism*
Mitochondrial Proteins / metabolism*
Mitophagy / genetics*
Muromegalovirus / immunology*

Substances

Membrane Proteins
Mitochondrial Proteins