Chondro-Osseous Lesions of Soft Tissue

Surg Pathol Clin. 2015 Sep;8(3):419-44. doi: 10.1016/j.path.2015.05.004.

Abstract

Soft tissue lesions can contain bone or cartilage matrix as an incidental, often metaplastic, phenomenon or as a diagnostic feature. The latter category includes a diverse group ranging from self-limited proliferations to benign neoplasms to aggressive malignancies. Correlating imaging findings with pathology is mandatory to confirm that a tumor producing bone or cartilage, in fact, originates from soft tissue rather than from the skeleton. The distinction can have dramatic diagnostic and therapeutic implications. This content focuses on the gross, histologic, radiographic, and clinical features of bone or cartilage-producing soft tissue lesions. Recent discoveries regarding tumor-specific genetics are discussed.

Keywords: Chondroma; Myositis ossificans; Ossifying fibromyxoid tumor; Osteosarcoma; Synovial chondromatosis.

Publication types

  • Review

MeSH terms

  • Bone Neoplasms / diagnosis*
  • Bone Neoplasms / genetics
  • Bone Neoplasms / pathology
  • Chondroma / diagnosis
  • Chondroma / genetics
  • Chondroma / pathology
  • Diagnosis, Differential
  • Fibroma / diagnosis
  • Fibroma / genetics
  • Fibroma / pathology
  • Genetic Predisposition to Disease
  • Humans
  • Myositis Ossificans / diagnosis
  • Myositis Ossificans / genetics
  • Myositis Ossificans / pathology
  • Osteosarcoma / diagnosis*
  • Osteosarcoma / genetics
  • Osteosarcoma / pathology
  • Prognosis
  • Soft Tissue Neoplasms / diagnosis*
  • Soft Tissue Neoplasms / genetics
  • Soft Tissue Neoplasms / pathology