Abstract
Based on the protonation/deprotonation of poly(β-amino ester) (PAE), mixed-shell micelles (MSMs) with adaptive surfaces could rapidly and reversibly change surface properties to prolong circulation time in blood (pH 7.4) and enhance cellular uptake at tumor sites (pH 6.5).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibiotics, Antineoplastic / administration & dosage
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / pharmacokinetics*
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Cell Survival / drug effects
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Doxorubicin / administration & dosage
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Doxorubicin / blood*
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Doxorubicin / pharmacokinetics*
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Drug Carriers / chemistry*
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Drug Carriers / pharmacokinetics
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Hep G2 Cells
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Humans
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Hydrogen-Ion Concentration
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Liver Neoplasms, Experimental / drug therapy
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Liver Neoplasms, Experimental / metabolism*
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Micelles
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Molecular Structure
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Nanostructures / chemistry*
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Polymers / chemistry
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Polymers / pharmacokinetics*
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Protons
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Surface Properties
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Time Factors
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Tissue Distribution
Substances
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Antibiotics, Antineoplastic
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Drug Carriers
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Micelles
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Polymers
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Protons
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poly(beta-amino ester)
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Doxorubicin