Discovery of oxathiapiprolin, a new oomycete fungicide that targets an oxysterol binding protein

Abstract

Oxathiapiprolin is the first member of a new class of piperidinyl thiazole isoxazoline fungicides with exceptional activity against plant diseases caused by oomycete pathogens. It acts via inhibition of a novel fungal target-an oxysterol binding protein-resulting in excellent preventative, curative and residual efficacy against key diseases of grapes, potatoes and vegetables. Oxathiapiprolin is being developed globally as DuPont™ Zorvec™ disease control with first registration and sales anticipated in 2015. The discovery, synthesis, optimization and biological efficacy are presented.

Keywords: Crop protection; Disease control; Oomycete fungicide; Oxathiapiprolin; Oxysterol binding protein.