Brain mitochondrial dysfunction has been demonstrated in diabetic animals with neurodegeneration. Protocatechuic acid (PCA), a major metabolite of anthocyanin, has been shown to exert glycemic control and oxidative stress reduction in the heart. However, its effects on oxidative stress and mitochondrial function in the brain under diabetic condition have never been investigated. We found that PCA exerted glycemic control, attenuates brain mitochondrial dysfunction, and contributes to the prevention of brain oxidative stress in diabetic rats.
Keywords: acide protocatéchique; brain mitochondria protocatechuic acid; diabète sucré insulinodépendant; insulin-dependent diabetes mellitus; mitochondrie cérébrale; oxidative stress; stress oxydatif.