Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations

Epigenomics. 2015 Aug;7(5):687-90. doi: 10.2217/epi.15.27. Epub 2015 Aug 28.
No abstract available

Keywords: EZH2; epigenetic reprogramming; epigenetic therapy; gain-of-function mutations; histone methylation; melanoma; polycomb.

Publication types

  • Editorial

MeSH terms

  • Enhancer of Zeste Homolog 2 Protein
  • Enzyme Inhibitors / therapeutic use
  • Epigenesis, Genetic*
  • Gene Expression Regulation, Enzymologic / drug effects
  • Gene Expression Regulation, Neoplastic / drug effects
  • Histones / metabolism
  • Humans
  • Lysine / metabolism
  • Methylation / drug effects
  • Molecular Targeted Therapy / methods
  • Mutation*
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Polycomb Repressive Complex 2 / antagonists & inhibitors
  • Polycomb Repressive Complex 2 / genetics*
  • Polycomb Repressive Complex 2 / metabolism

Substances

  • Enzyme Inhibitors
  • Histones
  • EZH2 protein, human
  • Enhancer of Zeste Homolog 2 Protein
  • Polycomb Repressive Complex 2
  • Lysine