Biomarkers for Primary Sjögren's Syndrome

Genomics Proteomics Bioinformatics. 2015 Aug;13(4):219-23. doi: 10.1016/j.gpb.2015.06.002. Epub 2015 Sep 8.

Abstract

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with exocrine gland dysfunction and multi-organ involvement. Recent progress in understanding the pathogenesis of pSS offers an opportunity to find new biomarkers for the diagnosis and assessment of disease activity. Screening noninvasive biomarkers from the saliva and tears has significant potential. The need for specific and sensitive biomarker candidates in pSS is significant. This review aims to summarize recent advances in the identification of biomarkers of Sjögren syndrome, trying to identify reliable, sensitive, and specific biomarkers that can be used to guide treatment decisions.

Keywords: Biomarker; Fms-like tyrosine kinase 3 ligand; Myxovirus-resistance protein A; Non-coding RNAs; Saliva; Sjögren syndrome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / analysis
  • Biomarkers / metabolism
  • Humans
  • Interferon Type I / metabolism
  • Membrane Proteins / metabolism
  • Saliva / chemistry
  • Saliva / metabolism*
  • Sjogren's Syndrome / diagnosis*
  • Sjogren's Syndrome / immunology
  • Sjogren's Syndrome / pathology
  • Tears / chemistry
  • Tears / metabolism*

Substances

  • Biomarkers
  • Interferon Type I
  • Membrane Proteins
  • flt3 ligand protein