Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1

Biochimie. 2015 Nov:118:173-5. doi: 10.1016/j.biochi.2015.09.009. Epub 2015 Sep 10.

Abstract

During clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for other applications. AS1411 is a nucleolin-targeting aptamer that underwent phase II clinical trials as anticancer agent. Here, we show that AS1411 exhibits extremely potent antiviral activity and is therefore an attractive new lead as anti-HIV agent.

Keywords: Anticancer; Antiviral; G-quadruplexes; Nucleolin; Zintevir.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • Antineoplastic Agents / pharmacology
  • Aptamers, Nucleotide
  • Cell Line
  • Cell Proliferation / drug effects
  • HIV-1 / drug effects*
  • Humans
  • Oligodeoxyribonucleotides / pharmacology*

Substances

  • AGRO 100
  • Anti-HIV Agents
  • Antineoplastic Agents
  • Aptamers, Nucleotide
  • Oligodeoxyribonucleotides