Keeping It in the Family: ATRX Loss Promotes Persistent Sister Telomere Cohesion in ALT Cancer Cells

Caitlin M Roake; Steven E Artandi

doi:10.1016/j.ccell.2015.08.005

Keeping It in the Family: ATRX Loss Promotes Persistent Sister Telomere Cohesion in ALT Cancer Cells

Cancer Cell. 2015 Sep 14;28(3):277-9. doi: 10.1016/j.ccell.2015.08.005.

Authors

Caitlin M Roake¹, Steven E Artandi²

Affiliations

¹ Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: sartandi@stanford.edu.

PMID: 26373274
DOI: 10.1016/j.ccell.2015.08.005

Abstract

In this issue of Cancer Cell, Ramamoorthy and Smith report that cancer cells that maintain their chromosome ends through alternative lengthening of telomeres (ALT) display persistent sister telomere cohesion. This delayed resolution of sister telomere cohesion depends upon the loss of ATRX and its histone-sequestering function and is associated with increased recombination between sister telomeres.

Publication types

Comment

MeSH terms

DNA Helicases / genetics*
Humans
Nuclear Proteins / genetics*
Recombination, Genetic / genetics*
Telomere / genetics*

Substances

Nuclear Proteins
DNA Helicases