Variation in apparent diffusion coefficient measurements among women with locally advanced cervical cancer

Abstract

ADC variability from mixed data sets acquired from women with locally advanced cervical cancer appears to be predominantly of biologic origin. Intra-histology ADC variance was similar when pooled across technical factors. Inter-histology pooling increased ADC variance. Normalization to urine ADC improved intra-histology variance and receiver-operator curve test performance.

Keywords: ADC; Cervical cancer; DWI.