A Comparison of Antibiotic Serum Concentrations Drawn Simultaneously from Peripherally Inserted Central Catheters and Peripheral Veins in Children with Respiratory Infection

J Pediatr Nurs. 2015 Nov-Dec;30(6):868-76. doi: 10.1016/j.pedn.2015.07.011. Epub 2015 Sep 15.

Abstract

The purpose of the study was to evaluate serum concentration of antibiotics drawn from a peripherally inserted central catheter (PICC) compared with a peripheral venipuncture. This prospective comparative study included patients with ages 1month to 21years admitted with a respiratory infection requiring IV vancomycin or IV tobramycin via a newly placed PICC. The difference between the antibiotic levels from the venipuncture and PICC samples was statistically significant for both the peak and trough levels. However, the difference in values was not enough to impact antibiotic dosing and therefore was not clinically significant.

Keywords: Antibiotic levels; CVC; Cystic fibrosis; PICC; Respiratory illness; Tobramycin; Vancomycin; Venipunctures.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / blood*
  • Catheterization, Central Venous / methods*
  • Catheterization, Peripheral / methods*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Hospitals, Pediatric
  • Humans
  • Prospective Studies
  • Respiratory Tract Infections / diagnosis
  • Respiratory Tract Infections / drug therapy*
  • Sensitivity and Specificity
  • Tobramycin / administration & dosage
  • Tobramycin / blood
  • Vancomycin / administration & dosage
  • Vancomycin / blood

Substances

  • Anti-Bacterial Agents
  • Vancomycin
  • Tobramycin