Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice

J Alzheimers Dis. 2015;46(4):849-53. doi: 10.3233/JAD-150031.

Abstract

Two tetrapeptides, HAEE and RADD, which are ionic-complementary to the primary zinc recognition site of amyloid-β (Aβ), have been reported to inhibit zinc-induced dimerization of the Aβ metal-binding domain and slow Aβ aggregation in vitro. In the present study, we investigate the impact of HAEE and RADD on the development of cerebral β-amyloidosis in a mouse model of Alzheimer's disease. We have found chronic intravenous administration of each peptide results in significant decrease of amyloid plaque burden in the treated mice.

Keywords: Alzheimer’s disease; amyloid-β; mouse models; protein aggregation in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / pathology*
  • Amyloid beta-Peptides / chemistry*
  • Amyloid beta-Protein Precursor / genetics
  • Animals
  • Antipsychotic Agents / therapeutic use*
  • Brain / drug effects
  • Brain / metabolism
  • Brain / pathology
  • Disease Models, Animal
  • Humans
  • Injections, Intravenous
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mutation / genetics
  • Oligopeptides / therapeutic use*
  • Plaque, Amyloid / drug therapy
  • Plaque, Amyloid / genetics
  • Presenilin-1 / genetics

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Antipsychotic Agents
  • Oligopeptides
  • Presenilin-1