Investigation on Abnormal Iron Metabolism and Related Inflammation in Parkinson Disease Patients with Probable RBD

Yang Hu; Shu-Yang Yu; Li-Jun Zuo; Ying-Shan Piao; Chen-Jie Cao; Fang Wang; Ze-Jie Chen; Yang Du; Teng-Hong Lian; Gai-Fen Liu; Ya-Jie Wang; Piu Chan; Sheng-Di Chen; Xiao-Min Wang; Wei Zhang

doi:10.1371/journal.pone.0138997

Investigation on Abnormal Iron Metabolism and Related Inflammation in Parkinson Disease Patients with Probable RBD

PLoS One. 2015 Oct 2;10(10):e0138997. doi: 10.1371/journal.pone.0138997. eCollection 2015.

Authors

Yang Hu¹, Shu-Yang Yu¹, Li-Jun Zuo², Ying-Shan Piao¹, Chen-Jie Cao², Fang Wang², Ze-Jie Chen², Yang Du², Teng-Hong Lian², Gai-Fen Liu³, Ya-Jie Wang⁴, Piu Chan⁵, Sheng-Di Chen⁶, Xiao-Min Wang⁷, Wei Zhang⁸

Affiliations

¹ Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
² Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
³ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
⁴ Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
⁵ Department of Neurology and Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 10053, China.
⁶ Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
⁷ Department of Physiology, Capital Medical University, Beijing, 100069, China.
⁸ Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China; Beijing Key Laboratory on Parkinson Disease, Beijing, 100053, China.

Abstract

Objective: To investigate potential mechanisms involving abnormal iron metabolism and related inflammation in Parkinson disease (PD) patients with probable rapid eye movement sleep behavior disorder (PRBD).

Methods: Total 210 PD patients and 31 controls were consecutively recruited. PD patients were evaluated by RBD Screening Questionnaire (RBDSQ) and classified into PRBD and probable no RBD (NPRBD) groups. Demographics information were recorded and clinical symptoms were evaluated by series of rating scales. Levels of iron and related proteins and inflammatory factors in cerebrospinal fluid (CSF) and serum were detected. Comparisons among control, NPRBD and PRBD groups and correlation analyses between RBDSQ score and levels of above factors were performed.

Results: (1) The frequency of PRBD in PD patients is 31.90%. (2) PRBD group has longer disease duration, more advanced disease stage, severer motor symptoms and more non-motor symptoms than NPRBD group. (3) In CSF, levels of iron, transferrin, NO and IL-1β in PRBD group are prominently increased. RBDSQ score is positively correlated with the levels of iron, transferrin, NO and IL-1β in PD group. Iron level is positively correlated with the levels of NO and IL-1β in PD group. (4) In serum, transferrin level is prominently decreased in PRBD group. PGE2 level in PRBD group is drastically enhanced. RBDSQ score exhibits a positive correlation with PGE2 level in PD group.

Conclusions: PRBD is common in PD patients. PRBD group has severer motor symptoms and more non-motor symptoms. Excessive iron in brain resulted from abnormal iron metabolism in central and peripheral systems is correlated with PRBD through neuroinflammation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Female
Humans
Inflammation / complications*
Iron / metabolism*
Male
Middle Aged
Parkinson Disease / complications
Parkinson Disease / metabolism*
REM Sleep Behavior Disorder / complications
REM Sleep Behavior Disorder / metabolism*

Substances

Iron

Grants and funding

This work is supported by the Beijing Healthcare Research Project (JING-15-2), the National Key Basic Research Program of China (2011CB504100), the National Natural Science Foundation of China (81071015, 30770745), the Natural Science Foundation of Beijing, China (7082032), the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2013BAI09B03), the project of Beijing Institute for Brain Disorders (BIBD PXM2013_014226_07_000084), the High Level Technical Personnel Training Project of Beijing Health System, China (2009-3-26), the Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality (IDHT20140514), the Capital Clinical Characteristic Application Research (Z121107001012161), the Excellent Personnel Training Project of Beijing, China (20071D0300400076), the Important National Science & Technology Specific Projects (2011ZX09102-003-01), the Key Project of National Natural Science Foundation of China (81030062), the Key Project of Beijing Natural Science Foundation (kz200910025001) and the Basic-Clinical Research Cooperation Funding of Capital Medical University (10JL49, 14JL15, 2015-JL-PT-X04).