Abstract
Cell division is a metabolically demanding process, requiring the production of large amounts of energy and biomass. Not surprisingly therefore, a cell's decision to initiate division is co-determined by its metabolic status and the availability of nutrients. Emerging evidence reveals that metabolism is not only undergoing substantial changes during the cell cycle, but it is becoming equally clear that metabolism regulates cell cycle progression. Here, we overview the emerging role of those metabolic pathways that have been best characterized to change during or influence cell cycle progression. We then studied how Notch signaling, a key angiogenic pathway that inhibits endothelial cell (EC) proliferation, controls EC metabolism (glycolysis) during the cell cycle.
Keywords:
angiogenesis; cell cycle; endothelial cell; metabolism; quiescence.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adaptor Proteins, Signal Transducing
-
Animals
-
Calcium-Binding Proteins
-
Cell Cycle Proteins / metabolism*
-
Cell Cycle*
-
Cell Proliferation*
-
Cells, Cultured
-
Energy Metabolism*
-
G1 Phase Cell Cycle Checkpoints
-
Glycolysis
-
Human Umbilical Vein Endothelial Cells / metabolism
-
Humans
-
Intercellular Signaling Peptides and Proteins / genetics
-
Intercellular Signaling Peptides and Proteins / metabolism
-
Phenotype
-
Phosphofructokinase-2 / genetics
-
Phosphofructokinase-2 / metabolism
-
Receptors, Notch / metabolism
-
Signal Transduction
-
Transfection
-
Ubiquitin-Protein Ligases / metabolism
Substances
-
Adaptor Proteins, Signal Transducing
-
Calcium-Binding Proteins
-
Cell Cycle Proteins
-
DLL4 protein, human
-
Intercellular Signaling Peptides and Proteins
-
Receptors, Notch
-
Ubiquitin-Protein Ligases
-
PFKFB3 protein, human
-
Phosphofructokinase-2