Hematopoietic Stem Cell Transplant for Mycosis Fungoides and Sézary Syndrome

Abstract

Mycosis fungoides (MF) and Sézary syndrome (SS) are common types of primary cutaneous T-cell lymphoma. Early-stage MF has a favorable prognosis and responds well to skin-directed regimens. Patients with advanced-stage MF, transformed MF, and SS are treated with combined systemic and skin-directed therapies. However, the disease is incurable with standard regimens, and frequent relapses are common. Owing to the lack of improvement in overall survival with standard regimens, hematopoietic stem cell transplant (HSCT) has been explored as a potential curative option. This article reviews the role of HSCT in MF/SS and discusses data regarding conditioning regimens, treatment-related complications, and outcomes.

Keywords: Allogeneic hematopoietic stem cell transplant; Autologous hematopoietic stem cell transplant; Cutaneous T-cell lymphoma; Mycosis fungoides; Myeloablative; Reduced-intensity conditioning; Sézary syndrome.