Abstract
Gliosarcoma is a rare primary malignant tumor of the central nervous system with poor prognosis. The median survival time of this disease ranges from 6 months to 14.8 months. However, a computer literature search indicated few long-term survivors. We investigated a case of a survivor of gliosarcoma with radiation-induced meningeal sarcomas, who showed no indication of recurrence for more than 9 years. A battery of molecular studies was performed to develop a molecular profile of this unique patient. We also reviewed the distinct clinical and molecular features of the tumor.
MeSH terms
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Adult
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DNA Modification Methylases
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DNA Repair Enzymes
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Disease-Free Survival
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Gene Expression Regulation, Neoplastic / radiation effects
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Gliosarcoma / diagnostic imaging
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Gliosarcoma / genetics
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Gliosarcoma / pathology
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Gliosarcoma / radiotherapy*
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Humans
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Isocitrate Dehydrogenase / genetics
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Magnetic Resonance Imaging
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Male
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Meningeal Neoplasms / diagnostic imaging
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Meningeal Neoplasms / genetics
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Meningeal Neoplasms / pathology
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Meningeal Neoplasms / radiotherapy*
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Neoplasms, Radiation-Induced / genetics
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Neoplasms, Radiation-Induced / pathology*
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PTEN Phosphohydrolase / biosynthesis
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Radiography
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Treatment Outcome
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Tumor Suppressor Proteins
Substances
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Tumor Suppressor Proteins
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IDH2 protein, human
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Isocitrate Dehydrogenase
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IDH1 protein, human
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DNA Modification Methylases
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MGMT protein, human
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PTEN Phosphohydrolase
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PTEN protein, human
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DNA Repair Enzymes