Selective CD28 antagonist prevents Aldara-induced skin inflammation in non-human primates

Nicolas Poirier; Mélanie Chevalier; Caroline Mary; Jérémy Hervouet; David Minault; Stéphanie Le Bas-Bernardet; Lyssia Belarif; Veronique Daguin; Elisabeth Cassagnau; Bernard Vanhove; Gilles Blancho

doi:10.1111/exd.12891

Selective CD28 antagonist prevents Aldara-induced skin inflammation in non-human primates

Exp Dermatol. 2016 Mar;25(3):233-4. doi: 10.1111/exd.12891. Epub 2016 Feb 10.

Authors

Nicolas Poirier^{1

2

3}, Mélanie Chevalier^{1

2

4}, Caroline Mary^{1

2

3}, Jérémy Hervouet^{1

2}, David Minault^{1

2}, Stéphanie Le Bas-Bernardet^{1

2

4}, Lyssia Belarif^{1

2

3}, Veronique Daguin^{1

2}, Elisabeth Cassagnau⁴, Bernard Vanhove^{1

2

3}, Gilles Blancho^{1

2

4}

Affiliations

¹ INSERM UMR 1064, Nantes, France.
² Institut de Transplantation Urologie Néphrologie (ITUN), Université de Nantes, Nantes, France.
³ Effimune, Nantes, France.
⁴ Centre Hospitalier Universitaire, Nantes, France.

PMID: 26513536
DOI: 10.1111/exd.12891

No abstract available

Keywords: Aldara; CD28; non-human primate; psoriasis; skin inflammation.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Topical
Aminoquinolines / adverse effects*
Animals
B7-1 Antigen / metabolism
B7-2 Antigen / metabolism
B7-H1 Antigen / metabolism
CD28 Antigens / antagonists & inhibitors*
CTLA-4 Antigen / metabolism
Imiquimod
Inflammation / chemically induced
Inflammation / drug therapy*
Lymphocyte Activation
Papio
Skin / drug effects*
T-Lymphocytes / cytology

Substances

Aminoquinolines
B7-1 Antigen
B7-2 Antigen
B7-H1 Antigen
CD28 Antigens
CTLA-4 Antigen
Imiquimod