Abstract
Non-histaminergic TRPA1 neural pathway is required for the development of allergic ocular itch. Pharmacological inhibition of TRPA1 channel can lead to novel therapeutic strategies to treat ocular itch in severe allergic conjunctivitis.
Publication types
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Letter
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Biomarkers / metabolism
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Conjunctivitis, Allergic / complications
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Conjunctivitis, Allergic / immunology*
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Histamine / metabolism*
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Mice
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Mice, Knockout
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Pruritus / immunology*
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TRPA1 Cation Channel
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TRPV Cation Channels / deficiency
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TRPV Cation Channels / immunology*
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Transient Receptor Potential Channels / deficiency
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Transient Receptor Potential Channels / immunology*
Substances
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Biomarkers
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TRPA1 Cation Channel
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TRPV Cation Channels
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TRPV1 protein, mouse
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Transient Receptor Potential Channels
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Trpa1 protein, mouse
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Histamine