Tropism distribution among antiretroviral-naive HIV-2-infected patients

AIDS. 2015 Oct 23;29(16):2209-12. doi: 10.1097/QAD.0000000000000825.

Abstract

The aim of this study was to describe HIV-2 R5/X4-tropism distribution in antiretroviral-naive HIV-2-infected patients. Population sequencing of the gp105 region was performed on peripheral blood mononuclear cells issued from 151 antiretroviral-naive patients. Tropism was successfully determined in 46 of 151 samples (30%) with six of 46 (13%) X4-tropic viruses. X4-tropism was associated with lower CD4 cell count (337 vs. 551/mm; P = 0.032) but not with plasma viral load. Thus, X4-tropism prevalence in HIV-2 antiretroviral-naive patients is similar to that observed in HIV-1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • HIV Infections / virology*
  • HIV-2 / genetics
  • HIV-2 / isolation & purification*
  • HIV-2 / physiology*
  • Humans
  • Leukocytes, Mononuclear / virology
  • Male
  • Middle Aged
  • Receptors, HIV / metabolism*
  • Sequence Analysis, DNA
  • Viral Tropism*
  • Virus Internalization
  • env Gene Products, Human Immunodeficiency Virus / genetics

Substances

  • Receptors, HIV
  • env Gene Products, Human Immunodeficiency Virus
  • gp105 envelope protein, Human immunodeficiency virus 2