Aging and Circadian Rhythms

Sleep Med Clin. 2015 Dec;10(4):423-34. doi: 10.1016/j.jsmc.2015.08.002. Epub 2015 Sep 15.

Abstract

Aging is associated with numerous changes, including changes in sleep timing, duration, and quality. The circadian timing system interacts with a sleep-wake homeostatic system to regulate human sleep, including sleep timing and structure. This article reviews key features of the human circadian timing system, age-related changes in the circadian timing system, and how those changes may contribute to the observed alterations in sleep.

Keywords: Aging; Circadian; Human; Light; Melatonin; Sleep.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aging / genetics
  • Aging / physiology*
  • Animals
  • Circadian Clocks / genetics
  • Circadian Clocks / physiology
  • Circadian Rhythm / genetics
  • Circadian Rhythm / physiology*
  • Humans
  • Sleep / genetics
  • Sleep / physiology