Chemical Constituents from the Fruiting Bodies of Hexagonia apiaria and Their Anti-inflammatory Activity

Tran Dinh Thang; Ping-Chung Kuo; Nguyen Thi Bich Ngoc; Tsong-Long Hwang; Mei-Lin Yang; Shih-Huang Ta; E-Jian Lee; Dai-Huang Kuo; Nguyen Huy Hung; Nguyen Ngoc Tuan; Tian-Shung Wu

doi:10.1021/acs.jnatprod.5b00449

Chemical Constituents from the Fruiting Bodies of Hexagonia apiaria and Their Anti-inflammatory Activity

J Nat Prod. 2015 Nov 25;78(11):2552-8. doi: 10.1021/acs.jnatprod.5b00449. Epub 2015 Nov 17.

Authors

Affiliations

¹ Department of Chemistry, Vinh University , Vinh City 42000, Vietnam.
² Department of Biotechnology, National Formosa University , Yunlin 63201, Taiwan, ROC.
³ Graduate Institute of Natural Products, Chang Gung University , Taoyuan 33302, Taiwan, ROC.
⁴ Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University , Taoyuan 33302, Taiwan, ROC.
⁵ Neurosurgical Service, Department of Surgery, National Cheng Kung Medical Center and Medical School , Tainan, Taiwan, ROC.
⁶ Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University , Pingtung 90741, Taiwan, ROC.
⁷ School of Pharmacy, National Cheng Kung University , Tainan 70101, Taiwan, ROC.

PMID: 26575215
DOI: 10.1021/acs.jnatprod.5b00449

Abstract

A chemical investigation of the fruiting bodies of Hexagonia apiaria resulted in the identification of nine compounds including five new triterpenoids, hexagonins A-E (1-5), along with four known compounds. The purified constituents were examined for their anti-inflammatory activity. Among the tested compounds, hexatenuin A displayed the most significant inhibition of superoxide anion generation and elastase release. These triterpenoids may have potentials as anti-inflammatory agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / blood
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification*
Anti-Inflammatory Agents / pharmacology
Fruiting Bodies, Fungal / chemistry*
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pancreatic Elastase / drug effects
Pancreatic Elastase / metabolism
Polyporaceae / chemistry*
Superoxides / metabolism
Triterpenes / blood
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology*

Substances

Anti-Inflammatory Agents
Triterpenes
hexagonin A
Superoxides
Pancreatic Elastase