DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis

Mingquan Sha; Genxiang Mao; Guofu Wang; Yufeng Chen; Xiaojian Wu; Zhen Wang

doi:10.1016/j.apsb.2015.01.011

DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis

Acta Pharm Sin B. 2015 May;5(3):188-93. doi: 10.1016/j.apsb.2015.01.011. Epub 2015 Apr 7.

Authors

Mingquan Sha¹, Genxiang Mao², Guofu Wang², Yufeng Chen³, Xiaojian Wu³, Zhen Wang¹

Affiliations

¹ Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
² Zhejiang Provincial Key Laboratory of Geriatrics & Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou 310013, China.
³ Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.

Abstract

EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation, metastasis and poor prognosis. Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer. 3-Deazaneplanocin A (DZNep), as an EZH2 inhibitor, can suppress cancer cell growth. However, the anti-cancer role of DZNep in colon cancer cells has been rarely studied. In this study, we demonstrate that DZNep can inhibit the growth and survival of colon cancer HCT116 cells by inducing cellular senescence and apoptosis. The study provides a novel view of anti-cancer mechanisms of DZNep in human colon cancer cells.

Keywords: Anti-cancer mechanisms; DZNep; EZH2; Human colon cancer HCT116 cells.